Acetaminophen Pathway (toxic doses), Pharmacokinetics Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Sex differences in glutathione metabolism and acetaminophen toxicity Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Full article: The development and hepatotoxicity of acetaminophen: reviewing over a century of progress