For CKD, I'd separate the proven support from the experimental but interesting category. Astragalus root extract is probably the most tried and true natural compound I'd look at first. There's actual human data showing Glutathione Skin Lightening Soap 75gm with Kojic Acid & Vitamin C, E Reduces Dark Spots, Wrinkles & Fine Lines What is Glutathione? What are the Benefits of Glutathione? JCI Insight Gut derived uremic toxin handling in vivo requires OAT mediated tubular secretion in chronic kidney disease Repression of the antiporter SLC7A11 glutathione glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification Kidney International