Amelanotic Melanoma: Symptoms, Outlook, and Treatment This lovely patient was thrilled with her beautiful result after laser treatment of oral melanotic macules. I share this case to educate: laser treatment requires accurate diagnosis, an understanding of the differential How Can You Tell if It's Melanoma or Just a Mole? Despite the name "melanosis," the pigment isn't melanin. The Pigment: It is actually lipofuscin, a "wear and tear" pigment. The Process: Anthraquinone laxatives cause apoptosis (cell death) of the colonic epithelial cells. Labial or Oral Melanotic Macule Benign, asymptomatic, and often underdiagnosed. Swipe to learn how to recognize, diagnose, and manage this simple yet important lesion! #thebasicdentist #rguhs #kuhs #tnmgrmu #OralPathology #MelanoticMacule #DentalFacts