Oral pathology: Noting a pigmented macule that often presents a diagnostic dilemma Registered Dental Hygienists What Caused These Multiple Hyperpigmented Macules of the Mouth? Labial Macules: Dark Spots on the Lip Dermatology Advisor Citalopram Induced Oral Melanotic Macules in a Female Patient and a Review of the Literature Cureus Happy Wednesday! , In this video, a patients labial melanotic macule (a benign pigmented lesion) is being treated with liquid nitrogen. Labial melanotic macules are flat and asymmetrical with a