How does CagriSema (Cagrilintide) Work? Cagrilintide Peptide for Weight Loss Appetite Control & Metabolic Support Cagrilintide, Tirzepatide, and Retatrutide Peptides: Comparing Metabolic Mechanisms Cagrilintide is an amylin analogue that helps regulate appetite. In a randomized trial of over 3400 patients who were overweight or obese and had 1 weight related complication, individuals assigned to a combination CagrilintideSemaglutide in Adults with Overweight or Obesity and Type 2 Diabetes New England Journal of Medicine