AngIV Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP PS1 Mouse via the PI3K AKT Signaling Pathway Dihexa Bioss Restoring the epigenome in Alzheimer's disease: advancing HDAC inhibitors as therapeutic agents ScienceDirect Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Dihexa Peptide for Cognition & Treating Neurodegeneration